Depression Undertreated? Yes, But…

Depression: An undertreated disorder?

In 1994, an estimated 6% of Canadians aged 18 and over—1.1 mi l l ion adults—experienced a Major Depressive Episode (MDE). Although depression is amenable to treatment, fewer than half (43%) the people who met the criteria of having experienced an MDE in the past year (approximately 487,000) reported talking to a health professional about their emotional or mental health. Furthermore, only 26% ...

Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated.

BACKGROUND Chromosome 22q11.2 deletion syndrome (22q11DS) is a common genetic disorder with high rates of psychosis and other psychopathologies, but few studies discuss treatment. Our aim was to characterize the prevalence and treatment of major psychiatric illnesses in a well-characterized sample of individuals with 22q11DS. METHOD This was a cross-sectional study of 112 individuals aged 8 t...

Antidepressants in bipolar depression: yes, no, maybe?

Antidepressants are widely used in the treatment of bipolar depression despite relatively meagre evidence for their efficacy and significant concerns that their prescription can precipitate an acute affective switch into mania/hypomania and that long-term administration can lead to mood instability. Therefore, the use of antidepressants to treat bipolar depression is an important but contentiou...

1 Causal Mechanisms : Yes , But ... [ extended version ]

Yes, but do they still get headaches?

Much of our present understanding of the action of prostaglandins derives from observing the effects of nonsteroidal anti-inflammatory drugs (NSAIDs). The anti-inflammatory, antipyretic, and analgesic effects resulting from inhibition of prostaglandin synthesis by aspirin, ibuprofen, and other NSAlDs indicate that these lipid-signaling molecules are critical regulators of immune responses, feve...